- The material of which the star is made, allows for disolving in a neutral pH but stability in an acidic environment (stomach)
- PCL was selected as one of the materials for rigid drug release matrix thanks to its bio-compatibility, low-temperature melt processing and established use in controlled drug delivery. It recoils within 5 to 30 minutes upon after the capsule is dissolved
- The device was 3D printed and designed in CAD
- Folding efficience decreases by 20% at 22Cº
- Linkers are made out of films of pH-dependent copolymers via solvent welding. They consist of blends of Eudragit L100-55
_16.42.43.png)
- Even after long periods of gastric residence, mucosal surfaces didn't show injury, erosions, any ulceration or muco-adhesion
- No special diet was necessary for pigs
- A powdered form of the drug was used in the first study
- The release of the drug can be tuned by varying the amount of drug including hydrophilic FDA-recognized ecxipient polymers such as polaxamers and methyl methacrylate copolymers. Drug release occurs through polymeric matrix erosion that opens channels, allowing the drug to diffuse out of the polymer